High cholesterol levels
High triglyceride levels
Guglipid offers considerable benefit in preventing and treating atherosclerotic vascular disease (Heart disease). It is most effective in lowering LDL cholesterol and triglycerides.It also raises the level of good cholesterol (HDL).
Guggul helps rid your body of harmful cholesterol by converting it into bile
Until recently the mechanism by which guggul lowers cholesterol was unclear. Now research published in Science Express (the on-line version of the renowned American journal, Science) shows that chemicals known as guggulsterones block the activity of the Farnesoid X Receptor (FXR), a protein which regulates cholesterol metabolism.
This receptor interferes in the process that converts cholesterol to bile acids. It prevents the body from eliminating excess cholesterol and increases the risk of heart disease.
David Moore of the Baylor College of Medicine in Houston found the guggul extract lives up to its reputation. "It really does lower cholesterol in a number of clinical studies in the Indian literature," Moore said.
Writing in the journal Science, he said the thorny myrrh tree has been used in Indian Ayurvedic medicine since at least 600 BC to treat obesity and other disorders.
Moore's team found the steroid guggulsterone, the active agent in the Guggul extract, blocks the activity of the farnesoid X receptor (FXR) on cells. FXR helps regulate cholesterol by affecting bile acids, which are produced from cholesterol and released by the liver.
"Bile acids are the only way that cholesterol has to get out of the body," Moore said in a telephone interview. "We knew that FXR was a key regulator of cholesterol metabolism."
Moore wanted to study FXR more, so he looked for compounds known to lower cholesterol whose mechanism of action was not understood. "I spent quite a lot of time clicking around the Internet," he said. He found guggul, along with niacin -- often prescribed for cholesterol patients -- and red wine, among others.
High cholesterol: Studies show that a 14-27% of LDL cholesterol and 22-30% of triglycerides levels were reduced when guggul was given to men and women with high cholesterol for 12 weeks with no change in diet or exercise. Several clinical studies were published in the Indian Journal of Medicine (volume 84) in 1986, Indian Pharmacoepia and in the Journal of the Association of Physicians in India (vol. 34 & 37) all stating the efficacy of guggul in lowering LDL cholesterol and triglycerides. Dr. David Moore and his team at the Baylor College of Medicine in Houston found that the guggulsterone, the active ingredient in the Guggul extract, blocks the activity of a receptor in the liver's cells called Farnesoid X Receptor (FXR). Later, Dr. David Mangelsdorf at University of Texas Southwestern Medical Center in Dallas confirmed that the guggul blocked the receptor and affected how cholesterol is metabolized.
Atherosclerosis: Two compounds, Z-guggulsterone and E-guggulsterone, appear to be responsible for guggul lipid's cholesterol-lowering effects. Guggul also appears to boost levels of "good" cholesterol although the exact mechanism is unknown. Both of these actions help prevent Atherosclerosis. Guggul is also an antioxidant, which helps stop the oxidization of cholesterol and the subsequent hardening of the arteries.
Impotence: Men with lower blood cholesterol or higher amounts of the beneficial high-density lipoprotein (HDL) cholesterol may be less likely to develop erectile dysfunction or impotence. Since guggul supports atherosclerosis (hardening of the arteries), which may impede blood flow to and from the penis, guggul may possibly be the treatment for impotence many men are looking for.
Weight Loss: Research with laboratory animals suggests guggul may help enhance thyroid function. Since the thyroid gland produces hormones that are needed to regulate metabolism, it can help in weight loss. Studies show guggul may change thyroid hormone metabolism, increase levels of circulating T3, or triiodothyroxine, a thyroxine metabolite known to raise overall metabolism, which in turn increases fat burning.
Other Conditions: Traditional Ayurvedic medicine suggests that Guggul helps increase white blood cell production, disinfects mucus, sweat, and urine and regulates menstruation.